DNA is often described as the instruction manual for building the fundamental components of life. Proteins are helpers that ...
We performed whole-transcriptome sequencing (n = 188) and exon capture DNA sequencing (n = 208) on pretreatment tumors from the CALGB 90601 randomized trial of gemcitabine/cisplatin plus bevacizumab ...
As people age, their immune systems deteriorate. This makes them more susceptible to infections and can mean that vaccines ...
If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...
Validation of a 15-Gene Prognostic Signature in Metastatic Clear Cell Renal Cell Carcinoma Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ...
DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among the most dangerous forms of DNA damage and immediately trigger the cell's ...
Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...
A previously unknown type of DNA damage in the mitochondria, the tiny power plants inside our cells, could shed light on how our bodies sense and respond to stress. The findings of the UC ...
Overcoming tumor resistance to chemotherapy drugs has long been a challenge for oncology clinicians and researchers. Now, a new study suggests that blocking a key protein, p300, may force damaged ...
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