Scientists have unearthed 188 previously unknown types of CRISPR systems buried in the genomes of simple microorganisms. Best known as a powerful gene-editing tool, CRISPR actually comes from an ...

Employing a metagenomic search, we identified a family of miniature CRISPR-Cas type V-L systems capable of RNA-guided dsDNA target cleavage without a tracrRNA. A bacterial depletion screen revealed ...

CRISPR-Cas systems are bacterial adaptive immune systems that target and cut the nucleic acids (DNA/RNA) of invading genetic parasites like bacteriophages (phages); viruses that infect - and ...

The cryogenic electron microscope structure of the A4p-activated (green) CalpL protein filament (violet) from Candidatus Cloacimonas acidaminovorans (PDB ID: 9EYJ). CRISPR-Cas systems help to protect ...

A new search algorithm has identified 188 kinds of new rare CRISPR systems in bacterial genomes, encompassing thousands of individual systems. The tool, which comes from the lab of CRISPR pioneer Feng ...

The clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated proteins (Cas) system is a bacterial defense mechanism that uses RNA-guided enzymes to cut specific sequences ...

CRISPR—Clustered Regularly Interspaced Short Palindromic Repeats—is the microbial world’s answer to adaptive immunity. Bacteria don’t generate antibodies when they are invaded by a pathogen and then ...

With the first medical therapy approved and systems like CRISPR-Cas showing up in complex cells, there’s a lot happening in the genome editing field. By Amber Dance/Knowable Magazine Published Jan 26, ...

2023 was the year that CRISPR gene-editing sliced its way out of the lab and into the public consciousness—and American medical system. The Food and Drug Administration recently approved the first ...