Wolff-Kishner Reduction

The Calm Before The Storm... ~ Classroom of the Elite Year 2 Volume 11

有机人名反应（143）：Japp–Klingemann hydrazone synthesis

The Wolff–Kishner reduction enables the complete deoxygenation of aldehydes and ketones to alkanes via hydrazone formation under strongly basic, high-temperature conditions. Developed by Ludwig Wolff and Nikolai Kishner in the early 20th century, the reaction proceeds through base-induced decomposition of the hydrazone with loss of dinitrogen, providing a thermodynamically driven reduction pathway. Learn. Review. Repeat.